Lymphocyte development: overview

Lymphocyte development: overview.

Lymphocyte development has always attracted the interest of researchers looking at it either as an easily accessible model of lineage determination and cellular differentiation in higher organisms or as the basis for an understanding of the immune system as such. The present collection of reviews contains examples of both categories, without of course comprehensively covering this vast area of ...

Lymphocyte development Editorial overview

During their development, lymphocytes acquire a remarkable ability to defend us from the universe of potential pathogens while maintaining tolerance to self. The study of lymphocyte development is important both for understanding how lymphocytes acquire their specificity and function, and for using as a model system of development. Indeed, the study of lymphocyte development involves the examin...

Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information.

Research on lymphocyte development and activation has matured to a level of sophistication that we can start to integrate multiple instructions coming from various players and understand how these instructive ‘networks’ govern lymphocyte function. The collection of reviews in this edition of Current Opinion in Immunology focuses on the complexity of intracellular cues that overcome a signal thr...

Lymphocyte Development — B- and T-Cell Development

WNT Signaling and Lymphocyte Development

Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.